VIA has just released the first quad-core mini-ITX boards on the market, but the interesting bit is in the ports. Yes, your craving for a 12-serial port mini-ITX board with four cores can now be sated.
There are two boards, the EPIA-M900 and EPIA-M910, both are mini-ITX boards with quad-core 1.2GHz Nano E-Series CPUs. The M900 is pretty vanilla for a mini-ITX quad core board, if you can say that without your head hurting. It has a PCIe 16x (8x electrical), GigE, PCI, 2 SATA, 8 USB2, 4 COM ports, VGA, HDMI, and 2 LVDS ports. It can also take 2 DDR3 SODIMMs totalling 8GB